br Due to fragility fractures observed in the
Due to fragility fractures observed in the IPA, and more so vantictumab, clinical programs, the Sponsor decided to discontinue IPA treatment for all patients in Cohorts 1 and 2 (5 and 10 mg/kg q3w, respectively). Subsequently, patients in Cohorts 3 and 4 were dosed at 2 and 4 mg/kg q3w, respective
br integrated into nano Se via electrostatic
integrated into nano-Se via electrostatic interaction (Fig. S6C). Besides, the hydrodynamic size of MCDION-Se exhibited no significant increase for 24 h, meanwhile the solution of MCDION-Se presented the typical "Tyndall Eﬀect" under illuminating with an external light source for standing time (Fig. S6E). These results suggested that MCDION-Se possessed excellent stability and could be well applied in vivo. Fur-thermore, MCDION-Se still showed excellent response ability to an external magneter (Fig. S6F), implying that MCDION-Se maintained good queneching ability for T1 imaging.
br X ray di raction XRD
X-ray diﬀraction (XRD) analysis displayed that all MCDIONs had the typical diﬀraction peaks of ION and MnCO3 (Fig. 2A), implying that MnCO3 was successfully integrated into IONs. The compositions of IONs and MCDIONs were investigated by Fourier transform infrared (FT-IR) spectroscopy. As shown in Fig. S3A, all samples had similar curves. The peaks at 586 cm−1 could be attributed to typical Fe-O stretching vi-bration. The peaks at 1048 and 1638 cm−1 were assigned to -C-N stretching vibration and -N-H bending vibration, demonstrating the existence of PEI chains in these particles .