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  • Medical Hypotheses br spiritual factors The material

    2020-08-28

     Medical Hypotheses 123 (2019) 60–62
    spiritual factors. The material and spiritual factors induce persistent stress which eventually leads to endocrine hypofunction even failure and unbalance of homeostasis. The disorder of biological signals of cell proliferation and differentiation facilitates tumor development.
    CRF and Many patients have been found tumors because of the symptoms of inappetence, fatigue, and emaciation. Even if no tumor be found at that time, various tumors would be found in the follow-up.
    Cancer, as a local lesion, is rarely life-threatening. Patient can sur-vive normally with tumor, and local treatment has good effect. Cancer as systemic disease, CC is the cause of death. Most of cancer patients do not die of tumor, but of CC. Eradiating tumor cell cannot cure the systemic cancerous disease; on the contrary, the poisonous side effect of therapies can speed up the progress of CC and death. For the systemic cancerous disease, it is important for curing CC and restoring the pa-tient's constitution to improve the quality of life and prolong the sur-vival.
    Data: The test of this theory
    1. Immune cell has endocrine hormone receptors on the surface, and endocrine cell has cytokine receptors. Endocrine system can reg-ulate the development of immune system, maturity of immune cell, and immune response by various hormones. Immune system also affects Peroxynitrite by cytokines. For example, inflammatory factors, like IL-1, IL-6, TNFα, can activate the hypothalamic-pitui-taryadrenal axis [6].
    2. Cancer cachexia exist excessive inflammatory response, there are an amount of inflammatory factors, such as IL-6, IL-10, IL-8 and TNFα. It is believed that IL-6, IL-10, IL-8, and TNFα play a core role in cancer cachexia, these inflammatory factors could trigger a series of neuroendocrine changes [7].
    3. The effects of chronic stress may increase incidence of cancer pos-sibly via shortening of telomeres [8].
    4. The disorder of biological Peroxynitrite signals has relationship with tumorigen-esis [9].
    Methods
    The method to verify this theory is as below.
    1. To examine the changes of endocrine function in cancer patients with cancer-related fatigue and cancer cachexia.
    2. To find more biological signals of cell proliferation and differ-entiation.
    3. To examine the changes of biological signals of cell proliferation and differentiation in cancer patients with cancer-related fatigue and cancer cachexia.
    Discussion
    Medical mode has transformed from biomedical mode to socio-psycho-biomedical mode. However, mainstream medicine is still ac-customed to using viewpoint of biomedical mode to study the disease. Biomedical mode believes that the measurable morphological changes in organic, cellular, biomolecular level are the causes of disease. By this viewpoint, cancer is undoubtedly a molecular disease. Tumor is dif-ferent from normal tissue, tumor cell is different from normal mature cell, the genetic phenotype of cancer cell is different from that of normal mature cell. There are so many measurable morphological changes in organic, tissular, cellular, biomacromolecular level, so cancer is undoubtedly a kind of genetic molecular disease. This is why the gene mutation theory is generally accepted and followed by main-stream medical community.
    Socio-psycho-biomedical mode believes that health is organic functional coordination and balance, and disease is unbalance of homeostasis. By this view, we can recognize a systemic cancerous
    disease. We can gain a better understanding of why cancer is related to natural physical, chemical, and biological factors, as well as negative spiritual factors, and why most cancer patients have symptoms of CRF and CC.
    Cancer, as a local lesion, is rarely life-threatening. Patient can sur-vive normally with tumor, and local treatment has good effect. Strategy of early detection and early therapy of cancer detects and treats more and more early local cancer that maybe do not need treatment. Cancer as systemic disease, systemic failure is the cause of death. Eradiating tumor cell cannot cure systemic cancerous disease; on the contrary, poisonous side effect of therapies speeds up the progress of cancer ca-chexia and death. This is why we query that eradiating tumor cell can cure some cancer but cannot cure all cancer, it is difficult to lengthen the survival time and improve quality of life of patient with CC by killing tumor. For the systemic cancerous patient, it is important for curing cancer cachexia and restoring the patient's constitution to pre-vent cancer and improve the quality of life and prolong the survival.
    Declaration of interests
    Appendix A. Supplementary data
    References
    Contents lists available at ScienceDirect
    Ecotoxicology and Environmental Safety
    journal homepage: www.elsevier.com/locate/ecoenv